Continual learning, the setting where a learning agent is faced with a never-ending stream of data, continues to be a great challenge for modern machine learning systems. In particular the online or "single-pass through the data" setting has gained attention recently as a natural setting that is difficult to tackle. Methods based on replay, either generative or from a stored memory, have been shown to be effective approaches for continual learning, matching or exceeding the state of the art in a number of standard benchmarks. These approaches typically rely on randomly selecting samples from the replay memory or from a generative model, which is suboptimal. In this work, we consider a controlled sampling of memories for replay. We retrieve the samples which are most interfered, i.e. whose prediction will be most negatively impacted by the foreseen parameters update. We show a formulation for this sampling criterion in both the generative replay and the experience replay setting, producing consistent gains in performance and greatly reduced forgetting. We release an implementation of our method at
NRXN1 is involved in synaptogenesis and have been implicated in Autism spectrum disorders. However, many rare inherited missense variants of NRXN1 have not been thoroughly evaluated. Here, functional analyses in vitro and in Drosophila of three NRXN1 missense mutations, Y282H, L893V, and I1135V identified in ASD patients in our previous study were performed. Our results showed these three mutations interfered protein degradation compared with NRXN1-WT protein. Expressing human NRXN1 in Drosophila could lead to abnormal circadian rhythm and sleep behavior, and three mutated proteins caused milder phenotypes, indicating the mutations may change the function of NRXN1 slightly. These findings highlight the functional role of rare NRXN1 missense variants identified in autism patients, and provide clues for us to better understand the pathogenesis of abnormal circadian rhythm and sleep behavior of other organisms, including humans.
interfered
Amazon illegally interfered in a recent union election at an Alabama warehouse, according to a statement on Thursday from the Retail, Wholesale and Department Store Union the union, which organized the campaign.
The RWDSU on Thursday filed objections to the National Labor Relations Board, claiming Amazon "created an atmosphere of confusion, coercion and/or fear of reprisals and thus interfered with the employees' freedom of choice" to join or reject a union.
Australian Information Commissioner and Privacy Commissioner Angelene Falk has determined that Uber Technologies, Inc. and Uber B.V. interfered with the privacy of an estimated 1.2 million Australians.
What Happened: Documents obtained under the Freedom of Information Act revealed that political appointees at the Census Bureau interfered with the 2020 census by altering technical aspects that could have caused inaccurate US population estimates.
Acting Attorney General Matthew Whitaker insisted on Friday that he had "not interfered" in the special counsel's Russia investigation as he faced a contentious and partisan congressional hearing in his waning days on the job."We have followed the special counsel's regulations to a T," Whitaker told the House Judiciary Committee. "There has been no event, no decision, that has required me to take any action, and I have not interfered in any way with the special counsel's investigation."He also said he had never discussed with the White House special counsel Robert Mueller's investigation into potential coordination between Russia and Donald Trump's campaign.The hearing was the first, and likely only, chance for newly empowered Democrats in the majority to grill an attorney general they perceive as a Trump loyalist and whose appointment they suspect was aimed at suppressing investigations of the Republican president. Republicans made clear they viewed the hearing as pointless political grandstanding especially since Whitaker may have less than a week left as the country's chief law enforcement officer."I'm thinking maybe we just set up a popcorn machine in the back," said Rep. Doug Collins, the committee's top Republican.Collins, of Georgia, called it a "dog and pony" show and criticized Democrats for disclosing derogatory information about Whitaker's business dealings hours before the hearing.Whitaker vented frustration early on as he repeatedly insisted that he would not discuss his conversations with Trump and tried to shift attention to the conventional work of the Justice Department."Mr. Chairman, I see that your five minutes are up," Whitaker said to the committee's Democratic leader, Rep. Jerrold Nadler of New York.But Nadler, who a day earlier had threatened to subpoena Whitaker to ensure his appearance, left no doubt about his party's focus."You decided that your private interest in overseeing this particular investigation - and perhaps others from which you should have been recused - was more important than the integrity of the department. The question that this Committee must now ask is: Why?"Whitaker laid the groundwork for a likely tussle with Democrats by saying in his opening statement that while he would address their questions, he would not reveal details of his communications with Trump."I trust that the members of this committee will respect the confidentiality that is necessary to the proper functioning of the presidency - just as we respect the confidentiality necessary to the legislative branch," Whitaker said.He told lawmakers that there has been no change since his arrival in the job in the "overall management" of Mueller's investigation. He said that he has run the Justice Department to the best of his ability, with "fidelity to the law and to the Constitution" and had never given any promises.Whitaker is likely in his final days as the country's chief law enforcement officer because the Senate plans to vote soon on confirming William Barr, Trump's pick for attorney general.Whitaker's highly anticipated testimony Friday had been in limbo after the Democratic-led committee approved a tentative subpoena to ensure that he appeared and answered questions. Whitaker responded by saying that he would not come unless the committee dropped its subpoena threat, which he called an act of "political theater."The stalemate ended Thursday evening after the committee chairman, Nadler, said the committee would not issue a subpoena if Whitaker appeared voluntarily.Democrats who perceive Whitaker as a Trump loyalist were expected to ask him whether he has made any commitments to the president about Mueller's Russia investigation and whether he has shared with Trump any inside information. Also expected to come up was Whitaker's comment last week that he believed the investigation into potential ties between Russia and the Trump campaign was nearly done.Democrats said they would inquire about Whitaker's past business dealings, too. Nadler and three other House committee chairmen released documents that they said show Whitaker failed to return thousands of dollars that were supposed to be distributed to victims of a company's alleged fraud.Whitaker has come under scrutiny for his involvement with the invention promotion company, which was accused of misleading consumers and has been under investigation by the FBI.Whitaker had been chief of staff to Attorney General Jeff Sessions, who was forced from the Cabinet last November as Trump seethed over Sessions' decision to step aside from overseeing the Russia investigation. Whitaker was an outspoken critic of the investigation before arriving at the Justice Department in 2017.Trump insists there was "no collusion" between his campaign and Russia.
A whistleblower lawsuit claims California State Polytechnic University, Pomona (Cal Poly Pomona) President Soraya Coley, who has held the position since Jan. 2015, has repeatedly interfered with campus criminal investigations.
The second incident in the lawsuit claims campus administration interfered with the investigation of a student who falsely reported identity theft. On Feb. 12, 2020, the lawsuit alleges a student filed a report with campus police claiming his debit card had been used without his permission over 40 times. Police determined 38 of the transactions were made by the student.
A deputy chief and a commander interfered with the probe launched after Sgt. Lori Rice died by suicide on Feb. 2, 2019, while returning after a night out with Sgt. Robert Garza, according to the quarterly report issued by interim Inspector General William Marbeck. That probe eventually discovered evidence of a scheme to defraud the department with phony time sheets, according to the watchdog's report.
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